||FOR RESEARCH USE ONLY (RUO).
||Recombinant-Human M-CSF-protein was developed from b.mori. For use in research applications.
||Recombinant M-CSFwas lyophilized from a.2 Mu m filtered PBS solution pH7.0 containing% HSA, % mannitol.
||Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
||The lyophilized protein is stable for at least years from date of receipt at-20°C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8°C for one month, or at-20°C for six months, with a carrier protein without detectable loss
||Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
| Post Translational Modifications || N- and O-glycosylated. Glycosylation and proteolytic cleavage yield different soluble forms. One high molecular weight soluble form is a proteoglycan containing chondroitin sulfate. O-glycosylated with core 1 or possibly core 8 glycans. Isoform 1 is N- and O-glycosylated. Isoform 3 is only N-glycosylated. |
| Function || Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. |
| Protein Name || Macrophage Colony-Stimulating Factor 1Csf-1M-CsfMcsfLanimostim Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 |
| Database Links || Reactome: R-HSA-381426Reactome: R-HSA-449836Reactome: R-HSA-6783783Reactome: R-HSA-8957275 |
| Cellular Localisation || Cell MembraneSingle-Pass Type I Membrane ProteinProcessed Macrophage Colony-Stimulating Factor 1: SecretedExtracellular Space |
| Alternative Antibody Names || Anti-Macrophage Colony-Stimulating Factor 1 antibodyAnti-Csf-1 antibodyAnti-M-Csf antibodyAnti-Mcsf antibodyAnti-Lanimostim Cleaved Into - Processed Macrophage Colony-Stimulating Factor 1 antibodyAnti-CSF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance