Human LYVE1 protein (Recombinant) (N-His-SUMO) (STJP009029)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LYVE1-N-His-SUMO protein was developed from e.coli for the region N-His-SUMO. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LYVE1 |
| Gene ID | 10894 |
| Uniprot ID | LYVE1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg26-Ser131 |
Additional Info
| Post Translational Modifications | O-glycosylated. |
| Function | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium. |
| Protein Name | Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1Lyve-1Cell Surface Retention Sequence-Binding Protein 1Crsbp-1Extracellular Link Domain-Containing Protein 1Hyaluronic Acid Receptor |
| Database Links | Reactome: R-HSA-2160916 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLocalized To The Plasma Membrane And In Vesicles Near Extranuclear Membranes Which May Represent Trans-Golgi Network (Tgn) And Endosomes/Prelysosomeal CompartmentsUndergoes Ligand-Dependent Internalization And Recycling At The Cell SurfaceLocalizes At Cell-Cell Junctions |
| Alternative Protein Names | Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 proteinLyve-1 proteinCell Surface Retention Sequence-Binding Protein 1 proteinCrsbp-1 proteinExtracellular Link Domain-Containing Protein 1 proteinHyaluronic Acid Receptor proteinLYVE1 proteinCRSBP1 proteinHAR proteinXLKD1 proteinUNQ230 proteinPRO263 protein |
Information sourced from Uniprot.org