Human LYPLAL1 protein (Recombinant) (His-Tag) (STJP017755)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human LYPLAL1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LYPLAL1 |
| Gene ID | 127018 |
| Uniprot ID | LYPL1_HUMAN |
| Accession Number | NP_620149 |
| Immunogen | Human |
| Immunogen Region | 1-237aa |
| Immunogen Sequence |
Additional Info
| Function | Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1. Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. |
| Protein Name | Lysophospholipase-Like Protein 1 |
| Database Links | |
| Cellular Localisation | Isoform 1: CytoplasmCytosolIsoform 2: Cytoplasm |
| Alternative Protein Names | Lysophospholipase-Like Protein 1 proteinLYPLAL1 protein |
Information sourced from Uniprot.org