Human LYPLA1 protein (Recombinant) (N-His) (STJP008004)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LYPLA1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LYPLA1 |
| Gene ID | 10434 |
| Uniprot ID | LYPA1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asp230 |
Additional Info
| Function | Acts as an acyl-protein thioesterase. Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1. Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes. Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS). Has much higher thioesterase activity than lysophospholipase activity. Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA. |
| Protein Name | Acyl-Protein Thioesterase 1Apt-1Hapt1Lysophospholipase 1Lysophospholipase ILpl-ILysopla IPalmitoyl-Protein Hydrolase |
| Database Links | Reactome: R-HSA-203615Reactome: R-HSA-9648002 |
| Cellular Localisation | CytoplasmCell MembraneNucleus MembraneEndoplasmic ReticulumShows Predominantly A Cytoplasmic Localization With A Weak Expression In The Cell MembraneNuclear Membrane And Endoplasmic Reticulum |
| Alternative Protein Names | Acyl-Protein Thioesterase 1 proteinApt-1 proteinHapt1 proteinLysophospholipase 1 proteinLysophospholipase I proteinLpl-I proteinLysopla I proteinPalmitoyl-Protein Hydrolase proteinLYPLA1 proteinAPT1 proteinLPL1 protein |
Information sourced from Uniprot.org