Human LRRC32/GARP protein (Recombinant) (C-His) (STJP009522)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LRRC32/GARP-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LRRC32 |
| Gene ID | 2615 |
| Uniprot ID | LRC32_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asn627 |
Additional Info
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). |
| Protein Name | Transforming Growth Factor Beta Activator Lrrc32GarpinGlycoprotein A Repetitions PredominantGarpLeucine-Rich Repeat-Containing Protein 32 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Protein Names | Transforming Growth Factor Beta Activator Lrrc32 proteinGarpin proteinGlycoprotein A Repetitions Predominant proteinGarp proteinLeucine-Rich Repeat-Containing Protein 32 proteinLRRC32 proteinD11S833E protein |
Information sourced from Uniprot.org