Human LRR1 protein (Recombinant) (N-His) (STJP008003)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LRR1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LRR1 |
| Gene ID | 122769 |
| Uniprot ID | LLR1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Lys135-Gly303 |
Additional Info
| Function | Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. |
| Protein Name | Leucine-Rich Repeat Protein 14-1bb-Mediated-Signaling Molecule4-1bblrrLrr-Repeat Protein 1Lrr-1Peptidylprolyl Isomerase-Like 5 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Leucine-Rich Repeat Protein 1 protein4-1bb-Mediated-Signaling Molecule protein4-1bblrr proteinLrr-Repeat Protein 1 proteinLrr-1 proteinPeptidylprolyl Isomerase-Like 5 proteinLRR1 proteinPPIL5 protein |
Information sourced from Uniprot.org