This LRP1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma or other biological fluids..
Applications
ELISA
Reactivity
Human
Sensitivity
0.061ng/mL
Detection Limit
0.156-10ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane. The N-terminus is blocked. Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1.
Function
Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. Also acts as a receptor for IGFBP3 to mediate cell growth inhibition. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
Protein Name
Prolow-Density Lipoprotein Receptor-Related Protein 1Lrp-1Alpha-2-Macroglobulin ReceptorA2mrApolipoprotein E ReceptorApoerCd Antigen Cd91 Cleaved Into - Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda SubunitLrp-85 - Low-Density Lipoprotein Receptor-Related Protein 1 515 Kda SubunitLrp-515 - Low-Density Lipoprotein Receptor-Related Protein 1 Intracellular DomainLrpicd
Low-Density Lipoprotein Receptor-Related Protein 1 85 Kda Subunit: Cell MembraneSingle-Pass Type I Membrane ProteinMembraneCoated PitLow-Density Lipoprotein Receptor-Related Protein 1 515 Kda Subunit: Cell MembranePeripheral Membrane ProteinExtracellular SideLow-Density Lipoprotein Receptor-Related Protein 1 Intracellular Domain: CytoplasmNucleusAfter CleavageThe Intracellular Domain (Lrpicd) Is Detected Both In The Cytoplasm And In The NucleusGolgi OutpostCytoplasmCytoskeletonMicrotubule Organizing CenterLocalizes To The Postsynaptic Golgi Apparatus RegionAlso Named Golgi OutpostWhich Shapes Dendrite Morphology By Functioning As Sites Of Acentrosomal Microtubule Nucleation
