Human LINGO1 protein (Recombinant) (C-His) (STJP007125)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LINGO1-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LINGO1 |
| Gene ID | 84894 |
| Uniprot ID | LIGO1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Cys42-Pro549 |
Additional Info
| Post Translational Modifications | N-glycosylated. Contains predominantly high-mannose glycans. |
| Function | Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. |
| Protein Name | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1Leucine-Rich Repeat Neuronal Protein 1Leucine-Rich Repeat Neuronal Protein 6a |
| Database Links | Reactome: R-HSA-193634 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 proteinLeucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1 proteinLeucine-Rich Repeat Neuronal Protein 1 proteinLeucine-Rich Repeat Neuronal Protein 6a proteinLINGO1 proteinLERN1 proteinLRRN6A proteinUNQ201 proteinPRO227 protein |
Information sourced from Uniprot.org