Human LINGO-1 protein (Recombinant) (His-Tag) (STJP019098)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human LINGO-1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LINGO1 |
| Gene ID | 84894 |
| Uniprot ID | LIGO1_HUMAN |
| Accession Number | NP_116197 |
| Immunogen | Human |
| Immunogen Region | 241-337aa |
| Immunogen Sequence | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSLKVL EISHWPYLDT MTPNCLYGLN LTSLSITHCN LTAVPYLAVR HLVYLRFLNL SYNPISTIEG SMLHELLRLQ EIQLVGGQLA VVEPYAFRGL NYL |
Additional Info
| Tissue Specificity | Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients. |
| Post Translational Modifications | N-glycosylated. Contains predominantly high-mannose glycans. |
| Function | Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. |
| Protein Name | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1Leucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1Leucine-Rich Repeat Neuronal Protein 1Leucine-Rich Repeat Neuronal Protein 6a |
| Database Links | Reactome: R-HSA-193634 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 proteinLeucine-Rich Repeat And Immunoglobulin Domain-Containing Protein 1 proteinLeucine-Rich Repeat Neuronal Protein 1 proteinLeucine-Rich Repeat Neuronal Protein 6a proteinLINGO1 proteinLERN1 proteinLRRN6A proteinUNQ201 proteinPRO227 protein |
Information sourced from Uniprot.org