Human LIMK2 protein (Recombinant) (N-His) (STJP007801)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LIMK2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LIMK2 |
| Gene ID | 3985 |
| Uniprot ID | LIMK2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp330-Pro638 |
Additional Info
| Function | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways.phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. |
| Protein Name | Lim Domain Kinase 2Limk-2 |
| Database Links | Reactome: R-HSA-3928662Reactome: R-HSA-416572Reactome: R-HSA-5627117 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleMicrotubule Organizing CenterCentrosomeIsoform Limk2a: CytoplasmNucleusIsoform Limk2b: CytoplasmPerinuclear RegionMainly Present In The Cytoplasm And Is Scarcely Translocated To The Nucleus |
| Alternative Protein Names | Lim Domain Kinase 2 proteinLimk-2 proteinLIMK2 protein |
Information sourced from Uniprot.org