Human LILRB2/ILT-4/CD85d protein (Recombinant) (C-hFc) (STJP019839)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Human LILRB2/ILT-4/CD85d Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-His458) of Human LILRB2/CD85d/ILT4 (Accession #Q8N423-1) fused with a C-hFc tag at the C-terminus.
General Information
| Short Description | Recombinant-Human LILRB2/ILT-4/CD85d-C-hFc protein was developed in hek293 cells using the region Gln22-His458. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | LILRB2 |
| Gene ID | 10288 |
| Uniprot ID | LIRB2_HUMAN |
| Immunogen | Recombinant Human LILRB2/ILT-4/CD85d Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln22-His458) of Human LILRB2/CD85d/ILT4 (Accession #Q8N423-1) fused with a C-hFc tag at the C-terminus. |
| Immunogen Region | Gln22-His458 |
| Immunogen Sequence | QTGTIPKPTLWAEPDSVITQ GSPVTLSCQGSLEAQEYRLY REKKSASWITRIRPELVKNG QFHIPSITWEHTGRYGCQYY SRARWSELSDPLVLVMTGAY PKPTLSAQPSPVVTSGGRVT LQCESQVAFGGFILCKEGED EHPQCLNSQPHARGSSRAIF SVGPVSPNRRWSHRCYGYDL NSPYVWSSPSDLLELLVPGV SKKPSLSVQPGPVMAPGESL TLQCVSDVGYDRFVLYKEG |
Additional Info
| Tissue Specificity | Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK) cells. Expressed in B cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2Lir-2Leukocyte Immunoglobulin-Like Receptor 2Cd85 Antigen-Like Family Member DImmunoglobulin-Like Transcript 4Ilt-4Monocyte/Macrophage Immunoglobulin-Like Receptor 10Mir-10Cd Antigen Cd85d |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 proteinLir-2 proteinLeukocyte Immunoglobulin-Like Receptor 2 proteinCd85 Antigen-Like Family Member D proteinImmunoglobulin-Like Transcript 4 proteinIlt-4 proteinMonocyte/Macrophage Immunoglobulin-Like Receptor 10 proteinMir-10 proteinCd Antigen Cd85d proteinLILRB2 proteinILT4 proteinLIR2 proteinMIR10 protein |
Information sourced from Uniprot.org