| Short Description : | Recombinant-Human LILRA3/CD85e-C-His protein was developed in hek293 cells using the region Gly24-Glu439. For use in research applications. |
| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <1 EU/Mu g |
| Gene Symbol: | LILRA3 |
| Gene ID: | 11026 |
| Uniprot ID: | LIRA3_HUMAN |
| Immunogen: | Recombinant Human LILRA3/CD85e Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly24-Glu439) of Human LILRA3 (Accession #NP_006856.3) fused with a 6×His tag at the C-terminus. |
| Immunogen Region: | Gly24-Glu439 |
| Immunogen Sequence: | GPLPKPTLWAEPGSVITQGS PVTLRCQGSLETQEYHLYRE KKTALWITRIPQELVKKGQF PILSITWEHAGRYCCIYGS HTAGLSESSDPLELVVTGAY SKPTLSALPSPVVTSGGNVT I QCDSQVAFDGFILCKEGE DEHPQCLNSHSHARGSSRAI FSVGPVSPSRRWSYRCYGYD SR APYVWSLPSDLLGLLVP GVSKKPSLSVQPGPVVAPGE KLTFQCGSDAGYDRFVLYKE |
| Post Translational Modifications | N-glycosylation is required for ligand binding. |
| Function | Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3Cd85 Antigen-Like Family Member EImmunoglobulin-Like Transcript 6Ilt-6Leukocyte Immunoglobulin-Like Receptor 4Lir-4Monocyte Inhibitory Receptor Hm43/Hm31Cd Antigen Cd85e |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 proteinCd85 Antigen-Like Family Member E proteinImmunoglobulin-Like Transcript 6 proteinIlt-6 proteinLeukocyte Immunoglobulin-Like Receptor 4 proteinLir-4 proteinMonocyte Inhibitory Receptor Hm43/Hm31 proteinCd Antigen Cd85e proteinLILRA3 proteinILT6 proteinLIR4 protein |
Information sourced from Uniprot.org
