Human LILRA3/CD85e protein (Recombinant) (C-His-Avi) {Biotin} (STJP001688)
SPECIFICATIONS
HostHEK293
ConjugationBiotin
ImmunogenDNA sequence encoding Human LILRA3/CD85e including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
General Information
| Short Description | Recombinant-Human LILRA3/CD85e-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications. |
| Host | HEK293 |
| Note | STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Dilution Range | Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM |
| Formulation | Lyophilised from 0.2 µm filtered PBS solution pH7.4. |
| Storage Instruction | The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. |
| Endotoxin | Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). |
Target Information
| Gene Symbol | LILRA3 |
| Gene ID | 11026 |
| Uniprot ID | LIRA3_HUMAN |
| Immunogen | DNA sequence encoding Human LILRA3/CD85e including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology. |
| Immunogen Region | Gly24-Glu439 |
Additional Info
| Post Translational Modifications | N-glycosylation is required for ligand binding. |
| Function | Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3Cd85 Antigen-Like Family Member EImmunoglobulin-Like Transcript 6Ilt-6Leukocyte Immunoglobulin-Like Receptor 4Lir-4Monocyte Inhibitory Receptor Hm43/Hm31Cd Antigen Cd85e |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 3 proteinCd85 Antigen-Like Family Member E proteinImmunoglobulin-Like Transcript 6 proteinIlt-6 proteinLeukocyte Immunoglobulin-Like Receptor 4 proteinLir-4 proteinMonocyte Inhibitory Receptor Hm43/Hm31 proteinCd Antigen Cd85e proteinLILRA3 proteinILT6 proteinLIR4 protein |
Information sourced from Uniprot.org