Human LGMN (Legumain) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016717)

Name: Human LGMN (Legumain) Sandwich ELISA Kit Ready-To-Use Kit (STJE0016717)
SKU: STJE0016717
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SPECIFICATIONS

STJE0016717

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Short Description	This LGMN Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates or other biological fluids..
Applications	ELISA
Reactivity	Human
Sensitivity	0.118ng/mL
Detection Limit	0.312-20ng/mL
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Storage Instruction	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time	3 hrs

Gene Symbol	LGMN
Gene ID	5641
Uniprot ID	LGMN_HUMAN
Immunogen Region	Ready-To-Use
Sample Type	serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Ubiquitous. Particularly abundant in kidney, heart and placenta.
Post Translational Modifications	Activated by autocatalytic processing at pH 4.
Function	Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation.
Protein Name	Legumain Asparaginyl Endopeptidase Aep Protease - Cysteine 1
Database Links	Reactome: R-HSA-1679131 Reactome: R-HSA-196791 Reactome: R-HSA-2132295
Cellular Localisation	Lysosome
Alternative ELISA Names	Legumain ELISA kit Asparaginyl Endopeptidase ELISA kit Aep ELISA kit Protease - Cysteine 1 ELISA kit LGMN ELISA kit PRSC1 ELISA kit
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Information sourced from Uniprot.org