Human LGMN (Legumain) Sandwich ELISA Kit (STJE0010330)
SPECIFICATIONS
General Information
| Short Description | This LGMN Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human serum, plasma, tissue homogenates, cell lysates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Human |
| Sensitivity | 0.118ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 4.5 hrs |
Target Information
| Gene Symbol | LGMN |
| Gene ID | 5641 |
| Uniprot ID | LGMN_HUMAN |
| Sample Type | serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
Additional Info
| Tissue Specificity | Ubiquitous. Particularly abundant in kidney, heart and placenta. |
| Post Translational Modifications | Activated by autocatalytic processing at pH 4. |
| Function | Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation. |
| Protein Name | LegumainAsparaginyl EndopeptidaseAepProtease - Cysteine 1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-196791Reactome: R-HSA-2132295 |
| Cellular Localisation | Lysosome |
| Alternative ELISA Names | Legumain ELISA kitAsparaginyl Endopeptidase ELISA kitAep ELISA kitProtease - Cysteine 1 ELISA kitLGMN ELISA kitPRSC1 ELISA kit |
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Information sourced from Uniprot.org