Human Leukotriene A4 Hydrolase/LTA4H protein (Recombinant) (His-Tag) (STJP019152)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Leukotriene A4 Hydrolase/LTA4H-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LTA4H |
| Gene ID | 4048 |
| Uniprot ID | LKHA4_HUMAN |
| Accession Number | NP_000886 |
| Immunogen | Human |
| Immunogen Region | 1-611aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMPEIVDT CSLASPASVC RTKHLHLRCS VDFTRRTLTG TAALTVQSQE DNLRSLVLDT KDLTIEKVVI NGQEVKYALG ERQSYKGSPM EISLPIALSK NQEIVIEISF ETSPKSSALQ WLTPEQTSGK EHPYLFSQCQ AIHCRAILPC QDTPSVKLTY TAEVSVPKEL VALMSAIRDG ETPDPEDPSR KIYKFIQKVP IPCYLIAL |
Additional Info
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts. |
| Post Translational Modifications | Phosphorylation at Ser-416 inhibits leukotriene-A4 hydrolase activity. |
| Function | Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the pro-inflammatory mediator leukotriene B4 (LTB4). Also has aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides. In addition to its pro-inflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions. |
| Protein Name | Leukotriene A-4 HydrolaseLta-4 HydrolaseLeukotriene A(4 HydrolaseTripeptide Aminopeptidase Lta4h |
| Database Links | Reactome: R-HSA-2142691Reactome: R-HSA-6798695Reactome: R-HSA-9018676Reactome: R-HSA-9018681Reactome: R-HSA-9018896Reactome: R-HSA-9020265Reactome: R-HSA-9023661 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Leukotriene A-4 Hydrolase proteinLta-4 Hydrolase proteinLeukotriene A(4 Hydrolase proteinTripeptide Aminopeptidase Lta4h proteinLTA4H proteinLTA4 protein |
Information sourced from Uniprot.org