| Post Translational Modifications | Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway. |
| Function | Transcription factor that binds DNA in a sequence-specific manner. Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling. May play a role in hair cell differentiation and follicle morphogenesis. Isoform 1: Transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. Isoform 3: Lacks the CTNNB1 interaction domain and may therefore be an antagonist for Wnt signaling. Isoform 5: Transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. |
| Protein Name | Lymphoid Enhancer-Binding Factor 1Lef-1T Cell-Specific Transcription Factor 1-AlphaTcf1-Alpha |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3769402Reactome: R-HSA-4086398Reactome: R-HSA-4411364Reactome: R-HSA-4641265Reactome: R-HSA-8853884Reactome: R-HSA-8951430Reactome: R-HSA-9616222Reactome: R-HSA-9733709Reactome: R-HSA-9754189Reactome: R-HSA-9793380Reactome: R-HSA-9796292Reactome: R-HSA-9824272Reactome: R-HSA-9824585Reactome: R-HSA-9825892Reactome: R-HSA-9856649 |
| Cellular Localisation | NucleusFound In Nuclear Bodies Upon Piasg Binding |
| Alternative Protein Names | Lymphoid Enhancer-Binding Factor 1 proteinLef-1 proteinT Cell-Specific Transcription Factor 1-Alpha proteinTcf1-Alpha proteinLEF1 protein |
Information sourced from Uniprot.org
