• Biotinylated Human LDLR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
  • The purity of Biotinylated Human LDLR is greater than 95% as determined by SEC-HPLC.

Human LDLR protein (Recombinant) (C-His-Avi) {Biotin} (STJP001711)

SKU:
STJP001711

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human LDLR-C-His-Avi protein was developed from hek293 and has a target region of C-His-Avi. For use in research applications.
Conjugation: Biotin
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Upon receipt centrifuge vial to ensure maximal product extraction, recommended: 20sec, 5K RPM
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C.
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg).
Gene Symbol: LDLR
Gene ID: 3949
Uniprot ID: LDLR_HUMAN
Immunogen Region: Ala22-Arg788
Immunogen: DNA sequence encoding Human LDLR including a C-His-Avi tag was expressed in HEK293 Cells. The recombinant protein was then biotinylated site specific using the AVItag biotinylation technology.
Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
Protein Name Low-Density Lipoprotein Receptor
Ldl Receptor
Database Links Reactome: R-HSA-8856825
Reactome: R-HSA-8856828
Reactome: R-HSA-8964026
Reactome: R-HSA-8964038
Reactome: R-HSA-975634
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane
Clathrin-Coated Pit
Golgi Apparatus
Early Endosome
Late Endosome
Lysosome
Rapidly Endocytosed Upon Ligand Binding
Alternative Protein Names Low-Density Lipoprotein Receptor protein
Ldl Receptor protein
LDLR protein

Information sourced from Uniprot.org

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