Human LCP2 protein (Recombinant) (N-T7 & C-His) (STJP014615)
SPECIFICATIONS
HostE.coli
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LCP2-N-T7 & C-His protein was developed from e.coli and has a target region of N-T7 & C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Supplied as a 0.22 Mu m filtered solution in 20mM Tris-HCl, 200mM NaCl, 20% Glycerol, pH 8.5. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | LCP2 |
| Gene ID | 3937 |
| Uniprot ID | LCP2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Pro533 |
Additional Info
| Post Translational Modifications | Phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2. SYK-dependent phosphorylation is required for recruitment of PI3K signaling components. |
| Function | Adapter protein primarily involved in signaling pathways within T-cells, as well as other immune cells such as platelets, mast cells, and natural killer (NK) cells. Plays a crucial role for transducing signal from the T-cell receptor (TCR) after antigen recognition leading to T-cell activation. Mechanistically, once phosphorylated by the kinase ZAP70, mediates interactions with the guanine-nucleotide exchange factor VAV1, the adapter protein NCK and the kinase ITK. In turn, stimulates the activation of PKC-theta/PRKCQ and NF-kappa-B transcriptional activity in response to CD3 and CD28 costimulation. Also plays an essential role in AGER-induced signaling pathways including p38 MAPK and ERK1/2 activation leading to cytokine release and pro-inflammatory responses. |
| Protein Name | Lymphocyte Cytosolic Protein 2Sh2 Domain-Containing Leukocyte Protein Of 76 KdaSlp-76 Tyrosine PhosphoproteinSlp76 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-202433Reactome: R-HSA-2424491Reactome: R-HSA-2871796Reactome: R-HSA-2871809 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Lymphocyte Cytosolic Protein 2 proteinSh2 Domain-Containing Leukocyte Protein Of 76 Kda proteinSlp-76 Tyrosine PhosphoproteinSlp76 proteinLCP2 protein |
Information sourced from Uniprot.org