| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.054ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This LCP1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | LCP1 |
| Gene ID: | 3936 |
| Uniprot ID: | PLSL_HUMAN |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T-lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells. |
| Post Translational Modifications | Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections. |
| Function | Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. |
| Protein Name | Plastin-2 L-Plastin Lc64p Lymphocyte Cytosolic Protein 1 Lcp-1 |
| Database Links | Reactome: R-HSA-8950505 |
| Cellular Localisation | Cytoplasm Cytoskeleton Cell Junction Cell Projection Ruffle Membrane Peripheral Membrane Protein Cytoplasmic Side Relocalizes To The Immunological Synapse Between Peripheral Blood T-Lymphocytes And Antibody-Presenting Cells In Response To Costimulation Through Tcr/Cd3 And Cd2 Or Cd28 Associated With The Actin Cytoskeleton At Membrane Ruffles Relocalizes To Actin-Rich Cell Projections Upon Serine Phosphorylation |
| Alternative ELISA Names | Plastin-2 ELISA kit L-Plastin ELISA kit Lc64p ELISA kit Lymphocyte Cytosolic Protein 1 ELISA kit Lcp-1 ELISA kit LCP1 ELISA kit PLS2 ELISA kit |
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Information sourced from Uniprot.org
