Human LBR protein (Recombinant) (N-GST & C-His) (STJP008807)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human LBR-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | LBR |
| Gene ID | 3930 |
| Uniprot ID | LBR_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ala7-Arg61 |
Additional Info
| Post Translational Modifications | Phosphorylated by CDK1 in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures. Phosphorylation of LBR and HP1 proteins may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated by SRPK1. In late anaphase LBR is dephosphorylated, probably by PP1 and/or PP2A, allowing reassociation with chromatin. |
| Function | Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane. |
| Protein Name | Delta(14-Sterol Reductase LbrDelta-14-Sr3-Beta-Hydroxysterol Delta14-ReductaseC-14 Sterol ReductaseC14srIntegral Nuclear Envelope Inner Membrane ProteinLmn2rLamin-B ReceptorSterol C14-Reductase |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2995383Reactome: R-HSA-8980692Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013408Reactome: R-HSA-9013423Reactome: R-HSA-9022692 |
| Cellular Localisation | Nucleus Inner MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmNucleusNuclear Rim |
| Alternative Protein Names | Delta(14-Sterol Reductase Lbr proteinDelta-14-Sr protein3-Beta-Hydroxysterol Delta protein14-Reductase proteinC-14 Sterol Reductase proteinC14sr proteinIntegral Nuclear Envelope Inner Membrane Protein proteinLmn2r proteinLamin-B Receptor proteinSterol C14-Reductase proteinLBR protein |
Information sourced from Uniprot.org