Human LAMTOR4 protein (Recombinant) (His-Tag) (STJP018887)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human LAMTOR4-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% Glycerol, 1mM DTT |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LAMTOR4 |
| Gene ID | 389541 |
| Uniprot ID | LTOR4_HUMAN |
| Accession Number | NP_001008396 |
| Immunogen | Human |
| Immunogen Region | 1-99aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSMTSALTQ GLERIPDQLG YLVLSEGAVL ASSGDLENDE QAASAISELV STACGFRLHR GMNVPFKRLS VVFGEHTLLV TVSGQRVFVV KRQNRGREPI DV |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-67 by PKA inhibits Ragulator complex assembly. |
| Function | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. |
| Protein Name | Ragulator Complex Protein Lamtor4Late Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | Lysosome |
| Alternative Protein Names | Ragulator Complex Protein Lamtor4 proteinLate Endosomal/Lysosomal Adaptor And Mapk And Mtor Activator 4 Cleaved Into - Ragulator Complex Protein Lamtor4 - N-Terminally Processed proteinLAMTOR4 proteinC7orf59 protein |
Information sourced from Uniprot.org