Human LAB7-1 (LAB7-1) Antibody Pair (STJAP00937)
General Information
| Short Description | This LAB7-1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL/0.5-4ug/mL |
| Dilution Range | 1:1000-1:10000 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
| Detection | Colorimetric method;ELISA;Sandwich |
Target Information
| Gene Symbol | CD80 |
| Gene ID | 941 |
| Uniprot ID | CD80_HUMAN |
| Sample Type | Serum, plasma and other biological fluids |
Additional Info
| Post Translational Modifications | Palmitoylated by ZDHHC20.palmitoylation protects CD80 from ubiquitin-mediated degradation, regulating the protein stability, and ensures its accurate plasma membrane localization. |
| Function | Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses. (Microbial infection) Acts as a receptor for adenovirus subgroup B. |
| Protein Name | T-Lymphocyte Activation Antigen Cd80Activation B7-1 AntigenBb1Ctla-4 Counter-Receptor B7.1B7Cd Antigen Cd80 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-389356Reactome: R-HSA-389357Reactome: R-HSA-389359Reactome: R-HSA-389513Reactome: R-HSA-6783783Reactome: R-HSA-6811558 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | T-Lymphocyte Activation Antigen Cd80 antibody pairActivation B7-1 Antigen antibody pairBb1 antibody pairCtla-4 Counter-Receptor B7.1 antibody pairB7 antibody pairCd Antigen Cd80 antibody pairCD80 antibody pairCD28LG antibody pairCD28LG1 antibody pairLAB7 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human LAB7-1 (LAB7-1) Antibody Pair (STJAP00937)
This antibody pair detects human LAB7-1 (UniProt P33681) and is validated for reactivity with human samples only.
The pair consists of two mouse-derived antibodies: one unconjugated and one biotin-conjugated, supplied at concentrations of 0.5 mg/mL and 0.5 to 4 ug/mL respectively.
This antibody pair is validated for use in sandwich ELISA with colorimetric detection. It has not been validated for other assay formats based on the information provided.
This antibody pair is suitable for use with serum, plasma, and other biological fluids in a sandwich ELISA format.
A dilution range of 1:1000 to 1:10000 is recommended, though optimal dilutions should be determined empirically for each specific experimental application.
Both components should be stored at -20 degrees Celsius for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain reagent integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.