Human KRT10 protein (Recombinant) (N-His) (STJP004070)

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STJP004070
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human KRT10-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: KRT10
Gene ID: 3858
Uniprot ID: K1C10_HUMAN
Immunogen Region: Leu153-Glu456
Immunogen: Homo sapiens (Human)
Function Plays a role in the establishment of the epidermal barrier on plantar skin. Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
Protein Name Keratin - Type I Cytoskeletal 10
Cytokeratin-10
Ck-10
Keratin-10
K10
Database Links Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Reactome: R-HSA-9725554
Cellular Localisation Secreted
Extracellular Space
Cell Surface
Cytoplasm
Alternative Protein Names Keratin - Type I Cytoskeletal 10 protein
Cytokeratin-10 protein
Ck-10 protein
Keratin-10 protein
K10 protein
KRT10 protein
KPP protein

Information sourced from Uniprot.org

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