Human KPNA1 protein (Recombinant) (N-His) (STJP004895)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KPNA1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KPNA1 |
| Gene ID | 3836 |
| Uniprot ID | IMA5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu239-Thr506 |
Additional Info
| Post Translational Modifications | Polyubiquitinated in the presence of RAG1 (in vitro). |
| Function | Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import.acts redundantly with KPNA2 and Transportin-1/TNPO1. (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. |
| Protein Name | Importin Subunit Alpha-5Karyopherin Subunit Alpha-1Nucleoprotein Interactor 1Npi-1Rag Cohort Protein 2Srp1-Beta Cleaved Into - Importin Subunit Alpha-5 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-140342Reactome: R-HSA-162592Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-180910Reactome: R-HSA-68616Reactome: R-HSA-909733Reactome: R-HSA-9636249 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Protein Names | Importin Subunit Alpha-5 proteinKaryopherin Subunit Alpha-1 proteinNucleoprotein Interactor 1 proteinNpi-1 proteinRag Cohort Protein 2 proteinSrp1-Beta Cleaved Into - Importin Subunit Alpha-5 - N-Terminally Processed proteinKPNA1 proteinRCH2 protein |
Information sourced from Uniprot.org