Human KMT5A protein (Recombinant) (N-His) (STJP007440)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KMT5A-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KMT5A |
| Gene ID | 387893 |
| Uniprot ID | KMT5A_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Leu263-His393 |
Additional Info
| Function | Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. |
| Protein Name | N-Lysine Methyltransferase Kmt5aH4-K20-Hmtase Kmt5aHistone-Lysine N-Methyltransferase Kmt5aLysine N-Methyltransferase 5aLysine-Specific Methylase 5aPr/Set Domain-Containing Protein 07Pr-Set7Pr/Set07Set Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-2299718Reactome: R-HSA-3214841Reactome: R-HSA-6804760 |
| Cellular Localisation | NucleusChromosomeSpecifically Localizes To Mitotic ChromosomesColocalized With Sirt2 At Mitotic FociAssociates With Chromosomes During MitosisAssociation Is Increased In A H(2)O(2)-Induced Oxidative Stress-Dependent MannerAssociates With Silent Chromatin On Euchromatic ArmsNot Associated With Constitutive Heterochromatin |
| Alternative Protein Names | N-Lysine Methyltransferase Kmt5a proteinH4-K20-Hmtase Kmt5a proteinHistone-Lysine N-Methyltransferase Kmt5a proteinLysine N-Methyltransferase 5a proteinLysine-Specific Methylase 5a proteinPr/Set Domain-Containing Protein 07 proteinPr-Set7 proteinPr/Set07 proteinSet Domain-Containing Protein 8 proteinKMT5A proteinPRSET7 proteinSET07 proteinSET8 proteinSETD8 protein |
Information sourced from Uniprot.org