Human KLRB1/CD161 protein (Recombinant) (C-His&Avi) {Biotin} (STJP019894)
SPECIFICATIONS
HostHEK293 cells
ConjugationBiotin
ImmunogenBiotinylated Recombinant Human KLRB1/CD161 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln67-Ser225) of Human KLRB1/CD161 (Accession #Q12918-1) fused with a C-His&Avi tag at the C-terminus.
General Information
| Short Description | Recombinant-Human KLRB1/CD161-C-His&Avi protein was developed in hek293 cells using the region Gln67-Ser225. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Biotin |
| Formulation | Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g of the protein by LAL method. |
Target Information
| Gene Symbol | KLRB1 |
| Gene ID | 3820 |
| Uniprot ID | KLRB1_HUMAN |
| Immunogen | Biotinylated Recombinant Human KLRB1/CD161 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln67-Ser225) of Human KLRB1/CD161 (Accession #Q12918-1) fused with a C-His&Avi tag at the C-terminus. |
| Immunogen Region | Gln67-Ser225 |
| Immunogen Sequence | QKSSIEKCSVDIQQSRNKTT ERPGLLNCPIYWQQLREKCL LFSHTVNPWNNSLADCSTKE SSLLLIRDKDELIHTQNLIR DKAILFWIGLNFSLSEKNWK WINGSFLNSNDLEIRGDAKE NSCISISQTSVYSEYCSTEI RWICQKELTPVRNKVYPDS |
Additional Info
| Tissue Specificity | Expressed in a subset of NK cells predominantly in intestinal epithelium and liver. Detected in peripheral blood T-cells and preferentially in adult T-cells with a memory antigenic phenotype. |
| Post Translational Modifications | N-glycosylated. Contains sialic acid residues. |
| Function | Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. |
| Protein Name | Killer Cell Lectin-Like Receptor Subfamily B Member 1C-Type Lectin Domain Family 5 Member BHnkr-P1aNkr-P1aNatural Killer Cell Surface Protein P1aCd Antigen Cd161 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Protein Names | Killer Cell Lectin-Like Receptor Subfamily B Member 1 proteinC-Type Lectin Domain Family 5 Member B proteinHnkr-P1a proteinNkr-P1a proteinNatural Killer Cell Surface Protein P1a proteinCd Antigen Cd161 proteinKLRB1 proteinCLEC5B proteinNKRP1A protein |
Information sourced from Uniprot.org