Human KLK8 protein (Recombinant-Active) (C-10*His) (STJP011736)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Active-Human KLK8-C-10*His protein was developed from mammalian cells and has a target region of C-10*His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | <0.1 EU/Mu g of the protein by the LAL method. |
| Immunoreactivity | Measured by its ability to cleave the fluorogenic peptide substrate BocVPR-AMC. The specific activity is >500 pmol/min/µg, as measured under the described conditions. |
Target Information
| Gene Symbol | KLK8 |
| Gene ID | 11202 |
| Uniprot ID | KLK8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln29-Gly260 |
Additional Info
| Function | Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. |
| Protein Name | Kallikrein-8Hk8NeuropsinNpOvasinSerine Protease 19Serine Protease Tadg-14Tumor-Associated Differentially Expressed Gene 14 Protein |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | SecretedCytoplasmShows A Cytoplasmic Distribution In The Keratinocytes |
| Alternative Protein Names | Kallikrein-8 proteinHk8 proteinNeuropsin proteinNp proteinOvasin proteinSerine Protease 19 proteinSerine Protease Tadg-14 proteinTumor-Associated Differentially Expressed Gene 14 Protein proteinKLK8 proteinNRPN proteinPRSS19 proteinTADG14 proteinUNQ283 proteinPRO322 protein |
Information sourced from Uniprot.org