Human KIM 1 (KIM 1) Antibody Pair (STJAP00887)
General Information
| Short Description | This KIM 1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R05-9P-4/R09-2J-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purification |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | HAVCR1 |
| Gene ID | 26762 |
| Uniprot ID | HAVR1_HUMAN |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. |
| Post Translational Modifications | Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis. |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. May play a role in kidney injury and repair. (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. TIM1 and Dengue virus are co-internalized during virus entry. (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. (Microbial infection) Plays a positive role in Chikungunya virus cell entry. |
| Protein Name | Hepatitis A Virus Cellular Receptor 1Havcr-1Kidney Injury Molecule 1Kim-1T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1Timd-1T-Cell Immunoglobulin Mucin Receptor 1TimTim-1T-Cell Membrane Protein 1Cd Antigen Cd365 |
| Database Links | Reactome: R-HSA-9694614 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Hepatitis A Virus Cellular Receptor 1 antibody pairHavcr-1 antibody pairKidney Injury Molecule 1 antibody pairKim-1 antibody pairT-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibody pairTimd-1 antibody pairT-Cell Immunoglobulin Mucin Receptor 1 antibody pairTim antibody pairTim-1 antibody pairT-Cell Membrane Protein 1 antibody pairCd Antigen Cd365 antibody pairHAVCR1 antibody pairKIM1 antibody pairTIM1 antibody pairTIMD1 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human KIM 1 (KIM 1) Antibody Pair (STJAP00887)
This antibody pair is designed to detect human KIM-1 (UniProt Q96D42), also known as Kidney Injury Molecule-1. Reactivity has been confirmed for human samples only.
Both antibodies are rabbit monoclonal IgGs supplied in unconjugated form, formulated in 0.01M PBS at pH 7.2, and purified by affinity chromatography. Clone R05-9P-4 and clone R09-2J-2 are provided as separate components within the pair.
This antibody pair is validated for use in ELISA. It is intended for sandwich ELISA development where one clone serves as the capture antibody and the other as the detection antibody.
Optimal working concentrations for both the capture and detection antibodies are to be determined by the end user. Titration experiments are recommended to establish the appropriate concentrations for each specific assay configuration.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and keep at -20°C, and avoid repeated freeze/thaw cycles to maintain activity.
Both antibodies were raised in rabbit against a recombinant human KIM-1 protein. No additional immunogen region details are specified in the product documentation.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.