Human KIM-1 (Hepatitis A Virus Cellular Receptor 1) Antibody Pair (STJAP00156)
General Information
| Short Description | This KIM-1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Applications | ELISA |
| Host | Mouse/Mouse |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Conjugation | Unconjugated/Biotin |
| Concentration | 0.5 mg/mL |
| Purification | Capture Purification: Protein A or G.Detection Purification: Protein A or G. |
| Formulation | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4.Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | HAVCR1 |
| Gene ID | 26762 |
| Uniprot ID | HAVR1_HUMAN |
| Immunogen | Capture immunogen: Recombinant Human KIM-1 protein.Detection Immunogen: Recombinant Human KIM-1 protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis. |
| Function | Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions. As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses. Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease. Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10. Acts as a regulator of T-cell proliferation. May play a role in kidney injury and repair. (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane. TIM1 and Dengue virus are co-internalized during virus entry. (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. (Microbial infection) Plays a positive role in Chikungunya virus cell entry. |
| Protein Name | Hepatitis A Virus Cellular Receptor 1Havcr-1Kidney Injury Molecule 1Kim-1T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1Timd-1T-Cell Immunoglobulin Mucin Receptor 1TimTim-1T-Cell Membrane Protein 1Cd Antigen Cd365 |
| Database Links | Reactome: R-HSA-9694614 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Pair Names | Hepatitis A Virus Cellular Receptor 1 antibody pairHavcr-1 antibody pairKidney Injury Molecule 1 antibody pairKim-1 antibody pairT-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 antibody pairTimd-1 antibody pairT-Cell Immunoglobulin Mucin Receptor 1 antibody pairTim antibody pairTim-1 antibody pairT-Cell Membrane Protein 1 antibody pairCd Antigen Cd365 antibody pairHAVCR1 antibody pairKIM1 antibody pairTIM1 antibody pairTIMD1 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Human KIM-1 (Hepatitis A Virus Cellular Receptor 1) Antibody Pair (STJAP00156)
This antibody pair detects human KIM-1, also known as Hepatitis A Virus Cellular Receptor 1 (UniProt Q96D42). Reactivity has been confirmed for human samples only.
Both antibodies are mouse monoclonal antibodies purified by Protein A or G. The capture antibody is supplied unconjugated, and the detection antibody is biotin-conjugated. Both are provided at 0.5 mg/mL in PBS containing 0.04% Proclin 300 and 50% glycerol at pH 7.4.
This antibody pair is validated for use in ELISA. No other assay formats are specified in the product documentation.
Both the capture and detection antibodies were raised against recombinant human KIM-1 protein. No further information on the specific immunogen region is provided for either component.
Both components should be stored at -20°C for long-term storage. Freeze-thaw cycles should be avoided to maintain antibody integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.