Human KCNMB1 protein (Recombinant) (N-His) (STJP015948)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KCNMB1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | KCNMB1 |
| Gene ID | 3779 |
| Uniprot ID | KCMB1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Pro40-Leu157 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. |
| Protein Name | Calcium-Activated Potassium Channel Subunit Beta-1Bk Channel Subunit Beta-1BkbetaBkbeta1Hbeta1Calcium-Activated Potassium Channel - Subfamily M Subunit Beta-1Calcium-Activated Potassium Channel Subunit BetaCharybdotoxin Receptor Subunit Beta-1K(Vcabeta-1Maxi K Channel Subunit Beta-1Slo-Beta-1Slo-Beta |
| Database Links | Reactome: R-HSA-1296052Reactome: R-HSA-418457Reactome: R-HSA-9662360Reactome: R-HSA-9667769 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Calcium-Activated Potassium Channel Subunit Beta-1 proteinBk Channel Subunit Beta-1 proteinBkbeta proteinBkbeta1 proteinHbeta1 proteinCalcium-Activated Potassium Channel - Subfamily M Subunit Beta-1 proteinCalcium-Activated Potassium Channel Subunit Beta proteinCharybdotoxin Receptor Subunit Beta-1 proteinK(Vcabeta-1 proteinMaxi K Channel Subunit Beta-1 proteinSlo-Beta-1 proteinSlo-Beta proteinKCNMB1 protein |
Information sourced from Uniprot.org