Human KCNIP3 protein (Recombinant) (His-Tag) (STJP016929)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human KCNIP3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol, 2mM DTT, 0.1M NaCl. |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNIP3 |
| Gene ID | 30818 |
| Uniprot ID | CSEN_HUMAN |
| Accession Number | NP_038462 |
| Immunogen | Human |
| Immunogen Region | 1-256aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG YITKEEMLAI MKSIYDMMGR HTYPILRE |
Additional Info
| Tissue Specificity | Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease. |
| Post Translational Modifications | Palmitoylated. Palmitoylation enhances association with the plasma membrane. Proteolytically cleaved by caspase-3. Phosphorylation at Ser-63 inhibits cleavage by CASP3. |
| Function | Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. |
| Protein Name | CalsenilinA-Type Potassium Channel Modulatory Protein 3Dre-Antagonist ModulatorDreamKv Channel-Interacting Protein 3Kchip3 |
| Database Links | Reactome: R-HSA-5576894Reactome: R-HSA-9768777 |
| Cellular Localisation | CytoplasmCell MembraneLipid-AnchorEndoplasmic ReticulumGolgi ApparatusNucleusAlso Membrane-BoundAssociated With The Plasma MembraneIn The Presence Of Psen2 Associated With The Endoplasmic Reticulum And GolgiThe Sumoylated Form Is Present Only In The Nucleus |
| Alternative Protein Names | Calsenilin proteinA-Type Potassium Channel Modulatory Protein 3 proteinDre-Antagonist Modulator proteinDream proteinKv Channel-Interacting Protein 3 proteinKchip3 proteinKCNIP3 proteinCSEN proteinDREAM proteinKCHIP3 protein |
Information sourced from Uniprot.org