Human KARS1 protein (Recombinant) (N-His) (STJP005421)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KARS1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KARS1 |
| Gene ID | 3735 |
| Uniprot ID | SYK_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg323-Arg553 |
Additional Info
| Function | Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. |
| Protein Name | Lysine--Trna LigaseLysyl-Trna SynthetaseLysrs |
| Database Links | Reactome: R-HSA-2408522Reactome: R-HSA-379716Reactome: R-HSA-379726Reactome: R-HSA-9856649 |
| Cellular Localisation | Isoform Cytoplasmic: CytoplasmCytosolCytoplasmNucleusCell MembranePeripheral Membrane ProteinSecretedSecretion Is Induced By Tnf-AlphaCytosolic In Quiescent Mast CellsTranslocates Into The Nucleus In Response To Mast Cell Activation By Immunoglobulin EIsoform Mitochondrial: Mitochondrion |
| Alternative Protein Names | Lysine--Trna Ligase proteinLysyl-Trna Synthetase proteinLysrs proteinKARS1 proteinKARS proteinKIAA0070 protein |
Information sourced from Uniprot.org