SDS-PAGE gel of recombinant human KARS protein 3 μg stained with Coomassie blue

Human KARS protein (Recombinant) (His-Tag) (STJP017296)

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STJP017296
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Short Description :Recombinant-Human KARS-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol, 0.1M NaCl, 1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:KARS1
Gene ID:3735
Uniprot ID:SYK_HUMAN
Accession Number:NP_005539.1
Immunogen:Human
Immunogen Region:63-597aa
Immunogen Sequence:GVGPEEE SVDPNQYYKI RSQAIHQLKV NGEDPYPHKF HVDISLTDFI QKYSHLQPGD HLTDITLKVA GRIHAKRASG GKLIFYDLRG EGVKLQVMAN SRNYKSEEEF IHINNKLRRG DIIGVQGNPG KTKKGELSII PYEITLLSPC LHMLPHLHFG LKDKETRYRQ RYLDLILNDF VRQKFIIRSK IITYIRSFLD ELGFLE
Post Translational Modifications Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE).
Function Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity. (Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
Protein Name Lysine--Trna Ligase
Lysyl-Trna Synthetase
Lysrs
Database Links Reactome: R-HSA-2408522
Reactome: R-HSA-379716
Reactome: R-HSA-379726
Reactome: R-HSA-9856649
Cellular Localisation Isoform Cytoplasmic: Cytoplasm
Cytosol
Cytoplasm
Nucleus
Cell Membrane
Peripheral Membrane Protein
Secreted
Secretion Is Induced By Tnf-Alpha
Cytosolic In Quiescent Mast Cells
Translocates Into The Nucleus In Response To Mast Cell Activation By Immunoglobulin E
Isoform Mitochondrial: Mitochondrion
Alternative Protein Names Lysine--Trna Ligase protein
Lysyl-Trna Synthetase protein
Lysrs protein
KARS1 protein
KARS protein
KIAA0070 protein

Information sourced from Uniprot.org

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