Human KANK2 protein (Recombinant) (N-His) (STJP011347)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human KANK2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | KANK2 |
| Gene ID | 25959 |
| Uniprot ID | KANK2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Asn161 |
Additional Info
| Post Translational Modifications | Phosphorylated by casein kinase II upon estrogen stimulation. Phosphorylation induces the release by KANK2 of NCOA1 and its translocation to the nucleus where NCOA1 can activate gene transcription. |
| Function | Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation. |
| Protein Name | Kn Motif And Ankyrin Repeat Domain-Containing Protein 2Ankyrin Repeat Domain-Containing Protein 25Matrix-Remodeling-Associated Protein 3Src-1-Interacting ProteinSipSrc-Interacting ProteinSrc1-Interacting Protein |
| Database Links | |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Protein Names | Kn Motif And Ankyrin Repeat Domain-Containing Protein 2 proteinAnkyrin Repeat Domain-Containing Protein 25 proteinMatrix-Remodeling-Associated Protein 3 proteinSrc-1-Interacting Protein proteinSip proteinSrc-Interacting Protein proteinSrc1-Interacting Protein proteinKANK2 proteinANKRD25 proteinKIAA1518 proteinMXRA3 proteinSIP protein |
Information sourced from Uniprot.org