Human Josephin 1/JOSD1 protein (Recombinant) (His-Tag) (STJP017864)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human Josephin 1/JOSD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 40% Glycerol, 5mM DTT, 2mM EDTA |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JOSD1 |
| Gene ID | 9929 |
| Uniprot ID | JOS1_HUMAN |
| Accession Number | NP_055691 |
| Immunogen | Human |
| Immunogen Region | 1-202aa |
| Immunogen Sequence |
Additional Info
| Post Translational Modifications | Monoubiquitinated. Ubiquitination activates deubiquitination activity in vitro. |
| Function | Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity. |
| Protein Name | Josephin-1Josephin Domain-Containing Protein 1 |
| Database Links | Reactome: R-HSA-5689877 |
| Cellular Localisation | Cell MembraneCytoplasmUbiquitination Increases Localization The Plasma MembraneIn The CytosolThe Unubiquitinated Form May Be Associated With The Cytoskeleton Via Actb-Binding |
| Alternative Protein Names | Josephin-1 proteinJosephin Domain-Containing Protein 1 proteinJOSD1 proteinJSPH1 proteinKIAA0063 protein |
Information sourced from Uniprot.org