Human JMJD7 protein (Recombinant) (His-Tag) (STJP018520)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human JMJD7-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 0.1M NaCl |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | JMJD7 |
| Gene ID | 100137047 |
| Uniprot ID | JMJD7_HUMAN |
| Accession Number | NP_001108104 |
| Immunogen | Human |
| Immunogen Region | 1-316aa |
| Immunogen Sequence |
Additional Info
| Function | Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Additionally, may play a role in protein biosynthesis by modifying the translation machinery. Acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA). |
| Protein Name | Bifunctional Peptidase And3s-Lysyl Hydroxylase Jmjd7Jmjc Domain-Containing Protein 7Jumonji Domain-Containing Protein 7L-Lysine3s-Hydroxylase Jmjd7 |
| Database Links | Reactome: R-HSA-9629569 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Bifunctional Peptidase And protein3s-Lysyl Hydroxylase Jmjd7 proteinJmjc Domain-Containing Protein 7 proteinJumonji Domain-Containing Protein 7 proteinL-Lysine protein3s-Hydroxylase Jmjd7 proteinJMJD7 protein |
Information sourced from Uniprot.org