Human IZUMO1R protein (Recombinant) (C-His) (STJP010133)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IZUMO1R-C-His protein was developed from mammalian cells for the region C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IZUMO1R |
| Gene ID | 390243 |
| Uniprot ID | JUNO_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gly20-Ser228 |
Additional Info
| Post Translational Modifications | The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm. |
| Function | Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. |
| Protein Name | Sperm-Egg Fusion Protein JunoFolate Receptor 4Folate Receptor DeltaFr-DeltaIzumo1 Receptor Protein Juno |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorCell ProjectionMicrovillus MembraneGpi-Anchored At The Oolemma Microvilli |
| Alternative Protein Names | Sperm-Egg Fusion Protein Juno proteinFolate Receptor 4 proteinFolate Receptor Delta proteinFr-Delta proteinIzumo1 Receptor Protein Juno proteinIZUMO1R proteinFOLR4 proteinJUNO protein |
Information sourced from Uniprot.org