SDS-PAGE gel of recombinant human IYD protein 3µg under reducing conditions Coomassie blue stain

Human IYD protein (Recombinant) (His-Tag) (STJP018691)

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STJP018691
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Short Description :Recombinant-Human IYD-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:IYD
Gene ID:389434
Uniprot ID:IYD1_HUMAN
Accession Number:NP_001158167
Immunogen:Human
Immunogen Region:24-214aa
Immunogen Sequence:DRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNE
Tissue Specificity Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
Function Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine. During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT). The scavanged iodide can then reenter the hormone-producing pathways. Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine.
Protein Name Iodotyrosine Deiodinase 1
Iyd-1
Iodotyrosine Dehalogenase 1
Database Links Reactome: R-HSA-209968
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Cytoplasmic Vesicle Membrane
Alternative Protein Names Iodotyrosine Deiodinase 1 protein
Iyd-1 protein
Iodotyrosine Dehalogenase 1 protein
IYD protein
C6orf71 protein
DEHAL1 protein

Information sourced from Uniprot.org

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