Human ITGB7 protein (Recombinant) (C-Strep) (STJP015087)
SPECIFICATIONS
HostMammalian Cells
ImmunogenHuman
General Information
| Short Description | Recombinant-Human ITGB7-C-Strep protein was developed from mammalian cells for the region C-Strep. For use in research applications. |
| Applications | SDS-PAGE/WB/ELISA/Immunogen |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Lyophilized from PBS pH7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-135°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ITGB7 |
| Gene ID | 3695 |
| Uniprot ID | ITB7_HUMAN |
| Immunogen | Human |
| Immunogen Region | Met1-His723 |
Additional Info
| Function | Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable). Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Also interacts with VCAM1 and fibronectin, an extracellular matrix component (Probable). It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable). Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable). Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin. (Microbial infection) Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. |
| Protein Name | Integrin Beta-7Gut Homing Receptor Beta Subunit |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-216083 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Integrin Beta-7 proteinGut Homing Receptor Beta Subunit proteinITGB7 protein |
Information sourced from Uniprot.org