Human ITGA3/CD49c protein (Recombinant) (N-His) (STJP015292)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ITGA3/CD49c-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact us for further information. |
Target Information
| Gene Symbol | ITGA3 |
| Gene ID | 3675 |
| Uniprot ID | ITA3_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Arg463-Asp757 |
Additional Info
| Post Translational Modifications | Isoform 1, but not isoform 2, is phosphorylated on serine residues. Phosphorylation increases after phorbol 12-myristate 13-acetate stimulation. |
| Function | Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. (Microbial infection) Integrin ITGA3:ITGB1 may act as a receptor for R.delemar CotH7 in alveolar epithelial cells, which may be an early step in pulmonary mucormycosis disease progression. |
| Protein Name | Integrin Alpha-3Cd49 Antigen-Like Family Member CFrp-2Galactoprotein B3Gapb3Vla-3 Subunit AlphaCd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-8874081 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLipid-AnchorCell ProjectionInvadopodium MembraneFilopodium MembraneEnriched Preferentially At InvadopodiaCell Membrane Protrusions That Correspond To Sites Of Cell InvasionIn A Collagen-Dependent Manner |
| Alternative Protein Names | Integrin Alpha-3 proteinCd49 Antigen-Like Family Member C proteinFrp-2 proteinGalactoprotein B3 proteinGapb3 proteinVla-3 Subunit Alpha proteinCd Antigen Cd49c Cleaved Into - Integrin Alpha-3 Heavy Chain - Integrin Alpha-3 Light Chain proteinITGA3 proteinMSK18 protein |
Information sourced from Uniprot.org