Human ISL1 protein (Recombinant) (N-His) (STJP005020)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ISL1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ISL1 |
| Gene ID | 3670 |
| Uniprot ID | ISL1_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Met1-Ala349 |
Additional Info
| Post Translational Modifications | Ubiquitinated probably by WWP1 E3 ubiquitin ligase.ubiquitination is followed by protein degradation. Phosphorylated. |
| Function | DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart. |
| Protein Name | Insulin Gene Enhancer Protein Isl-1Islet-1 |
| Database Links | Reactome: R-HSA-400511Reactome: R-HSA-9010553Reactome: R-HSA-9733709 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Insulin Gene Enhancer Protein Isl-1 proteinIslet-1 proteinISL1 protein |
Information sourced from Uniprot.org