Human IRF4 protein (Recombinant) (N-His) (STJP005442)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IRF4-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IRF4 |
| Gene ID | 3662 |
| Uniprot ID | IRF4_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu130-Glu451 |
Additional Info
| Post Translational Modifications | Phosphorylation by ROCK2 regulates IL-17 and IL-21 production. |
| Function | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes. |
| Protein Name | Interferon Regulatory Factor 4Irf-4Lymphocyte-Specific Interferon Regulatory FactorLsirfMultiple Myeloma Oncogene 1Nf-Em5 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-909733Reactome: R-HSA-9725371Reactome: R-HSA-9824585 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Protein Names | Interferon Regulatory Factor 4 proteinIrf-4 proteinLymphocyte-Specific Interferon Regulatory Factor proteinLsirf proteinMultiple Myeloma Oncogene 1 proteinNf-Em5 proteinIRF4 proteinMUM1 protein |
Information sourced from Uniprot.org