Human ING2 protein (Recombinant) (N-GST & C-His) (STJP007588)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human ING2-N-GST & C-His protein was developed from e.coli for the region N-GST & C-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | ING2 |
| Gene ID | 3622 |
| Uniprot ID | ING2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu204-Glu263 |
Additional Info
| Post Translational Modifications | Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. |
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). |
| Protein Name | Inhibitor Of Growth Protein 2Inhibitor Of Growth 1-Like ProteinIng1lpP32P33ing2 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-6811555 |
| Cellular Localisation | NucleusPredominantly NuclearLocalized To Chromatin And Nuclear MatrixUpon Reduced Ptdins(5)P Levels Seems To Be Released From Chromatin AndAt Least PartiallyTranslocated To The Cytoplasm |
| Alternative Protein Names | Inhibitor Of Growth Protein 2 proteinInhibitor Of Growth 1-Like Protein proteinIng1lp proteinP32 proteinP33ing2 proteinING2 proteinING1L protein |
Information sourced from Uniprot.org