Human IMPDH2 protein (Recombinant) (N-His) (STJP004032)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IMPDH2-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IMPDH2 |
| Gene ID | 3615 |
| Uniprot ID | IMDH2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp226-Phe514 |
Additional Info
| Post Translational Modifications | Ubiquitinated leading to its degradation by the proteasome. The N-terminus is blocked. Acetylated by CLOCK in a circadian manner. |
| Function | Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. |
| Protein Name | Inosine-5'-Monophosphate Dehydrogenase 2Imp Dehydrogenase 2Impd 2Impdh 2Inosine-5'-Monophosphate Dehydrogenase Type IiImp Dehydrogenase IiImpdh-Ii |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-73817Reactome: R-HSA-9679191Reactome: R-HSA-9748787 |
| Cellular Localisation | CytoplasmNucleusCytosolCan Form Fiber-Like Subcellular Structures Termed 'Cytoophidia' In Response To Intracellular Guanine-Nucleotide Depletion |
| Alternative Protein Names | Inosine-5'-Monophosphate Dehydrogenase 2 proteinImp Dehydrogenase 2 proteinImpd 2 proteinImpdh 2 proteinInosine-5'-Monophosphate Dehydrogenase Type Ii proteinImp Dehydrogenase Ii proteinImpdh-Ii proteinIMPDH2 proteinIMPD2 protein |
Information sourced from Uniprot.org