Human IMPAD1 protein (Recombinant) (His-Tag) (STJP019073)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human IMPAD1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | Enzyme Activity/SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity | Specific acitivty > 3300pmol/min/ug, its ability to dephosphorylate adenosine 3 5 NA-diphosphate sodium slat at pH 7.5, 25C. |
Target Information
| Gene Symbol | BPNT2 |
| Gene ID | 54928 |
| Uniprot ID | IMPA3_HUMAN |
| Accession Number | NP_060283 |
| Immunogen | Human |
| Immunogen Region | 34-359aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSGRFSLFG LGGEPGGGAA GPAAAADGGT VDLREMLAVS VLAAVRGGDE VRRVRESNVL HEKSKGKTRE GAEDKMTSGD VLSNRKMFYL LKTAFPSVQI NTEEHVDAAD QEVILWDHKI PEDILKEVTT PKEVPAESVT VWIDPLDATQ EYTEDLRKYV TTMVCVAVNG KPMLGVIHKP FSEYTAWAMV DGGSNVKARS SYNEKTPR |
Additional Info
| Post Translational Modifications | Contains N-linked glycan resistant to endoglycosydase H. |
| Function | Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4. |
| Protein Name | Golgi-Resident Adenosine 3' -5'-Bisphosphate 3'-PhosphataseGolgi-Resident Pap PhosphataseGpapp3'(2' - 5'-Bisphosphate Nucleotidase 2Inositol Monophosphatase Domain-Containing Protein 1Myo-Inositol Monophosphatase A3Phosphoadenosine Phosphate 3'-Nucleotidase |
| Database Links | Reactome: R-HSA-156584 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneSingle-Pass Type Ii Membrane ProteinThe Catalytic Core Is Predicted To Reside Within The Golgi Lumen |
| Alternative Protein Names | Golgi-Resident Adenosine 3' -5'-Bisphosphate 3'-Phosphatase proteinGolgi-Resident Pap Phosphatase proteinGpapp protein3'(2' - 5'-Bisphosphate Nucleotidase 2 proteinInositol Monophosphatase Domain-Containing Protein 1 proteinMyo-Inositol Monophosphatase A3 proteinPhosphoadenosine Phosphate 3'-Nucleotidase proteinBPNT2 proteinIMPA3 proteinIMPAD1 protein |
Information sourced from Uniprot.org