Human IMPA1/IMP1 protein (Recombinant) (His-Tag) (STJP016877)

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STJP016877
£134.50 - £738.50
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Short Description :Recombinant-Human IMPA1/IMP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:IMPA1
Gene ID:3612
Uniprot ID:IMPA1_HUMAN
Accession Number:NP_005527
Immunogen:Human
Immunogen Region:1-277aa
Immunogen Sequence: MADPWQECMD YAVTLARQAG EVVCEAIKNE MNVMLKSSPV DLVTATDQKV EKMLISSIKE KYPSHSFIGE ESVAAGEKSI LTDNPTWIID PIDGTTNFVH RFPFVAVSIG FAVNKKIEFG VVYSCVEGKM YTARKGKGAF CNGQKLQVSQ QEDITKSLLV TELGSSRTPETVRMVLSNME KLFCIPVHGI RSVGTAAVNM CLVATGG
Function Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder. Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate.
Protein Name Inositol Monophosphatase 1
Imp 1
Impase 1
D-Galactose 1-Phosphate Phosphatase
Inositol-1(Or 4-Monophosphatase 1
Lithium-Sensitive Myo-Inositol Monophosphatase A1
Database Links Reactome: R-HSA-1855183
Cellular Localisation Cytoplasm
Alternative Protein Names Inositol Monophosphatase 1 protein
Imp 1 protein
Impase 1 protein
D-Galactose 1-Phosphate Phosphatase protein
Inositol-1(Or 4-Monophosphatase 1 protein
Lithium-Sensitive Myo-Inositol Monophosphatase A1 protein
IMPA1 protein
IMPA protein

Information sourced from Uniprot.org