Human IMPA1/IMP1 protein (Recombinant) (His-Tag) (STJP016877)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human IMPA1/IMP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 1 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IMPA1 |
| Gene ID | 3612 |
| Uniprot ID | IMPA1_HUMAN |
| Accession Number | NP_005527 |
| Immunogen | Human |
| Immunogen Region | 1-277aa |
| Immunogen Sequence |
Additional Info
| Function | Phosphatase involved in the dephosphorylation of myo-inositol monophosphates to generate myo-inositol. Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate. Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP. Responsible for the provision of inositol required for synthesis of phosphatidylinositols and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium (Li(+)) action in brain, which is used to treat bipolar affective disorder. Is equally active with 1D-myo-inositol 1-phosphate, 1D-myo-inositol 3-phosphate and D-galactose 1-phosphate. |
| Protein Name | Inositol Monophosphatase 1Imp 1Impase 1D-Galactose 1-Phosphate PhosphataseInositol-1(Or 4-Monophosphatase 1Lithium-Sensitive Myo-Inositol Monophosphatase A1 |
| Database Links | Reactome: R-HSA-1855183 |
| Cellular Localisation | Cytoplasm |
| Alternative Protein Names | Inositol Monophosphatase 1 proteinImp 1 proteinImpase 1 proteinD-Galactose 1-Phosphate Phosphatase proteinInositol-1(Or 4-Monophosphatase 1 proteinLithium-Sensitive Myo-Inositol Monophosphatase A1 proteinIMPA1 proteinIMPA protein |
Information sourced from Uniprot.org