Human IMP Dehydrogenase 1/IMPDH1 protein (Recombinant) (His-Tag) (STJP016726)

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STJP016726
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Short Description :Recombinant-Human IMP Dehydrogenase 1/IMPDH1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 20% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:IMPDH1
Gene ID:3614
Uniprot ID:IMDH1_HUMAN
Accession Number:NP_001136045
Immunogen:Human
Immunogen Region:1-514aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MADYLISGGT GYVPEDGLTA QQLFASADGL TYNDFLILPG FIDFIADEVD LTSALTRKIT LKTPLISSPM DTVTEADMAI AMALMGGIGF IHHNCTPEFQ ANEVRKVKKF EQGFITDPVV LSPSHTVGDV LEAKMRHGFS GIPITETGTM GSKLVGIVTS RDIDFLAEKD HTTLLSEVMT PRIELVVAPA GVTLKEANEI LQRSKKGK
Tissue Specificity IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Function Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Protein Name Inosine-5'-Monophosphate Dehydrogenase 1
Imp Dehydrogenase 1
Impd 1
Impdh 1
Impdh-I
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-73817
Reactome: R-HSA-9679191
Reactome: R-HSA-9748787
Cellular Localisation Cytoplasm
Nucleus
Alternative Protein Names Inosine-5'-Monophosphate Dehydrogenase 1 protein
Imp Dehydrogenase 1 protein
Impd 1 protein
Impdh 1 protein
Impdh-I protein
IMPDH1 protein
IMPD1 protein

Information sourced from Uniprot.org

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