Human IL8/CXCL8 protein (Recombinant) (C-His) (STJP013162)
SPECIFICATIONS
HostMammalian Cells
ConjugationUnconjugated
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IL8/CXCL8-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications. |
| Applications | ELISA/WB |
| Host | Mammalian Cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a 0.22 Mu m filtered solution in 20mM PB, 150mM NaCl, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | < 1 EU/µg as determined by LAL test. |
Target Information
| Gene Symbol | CXCL8 |
| Gene ID | 3576 |
| Uniprot ID | IL8_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Glu21-Ser99 |
Additional Info
| Function | Chemotactic factor that mediates inflammatory response by attracting neutrophils, basophils, and T-cells to clear pathogens and protect the host from infection. Also plays an important role in neutrophil activation. Released in response to an inflammatory stimulus, exerts its effect by binding to the G-protein-coupled receptors CXCR1 and CXCR2, primarily found in neutrophils, monocytes and endothelial cells. G-protein heterotrimer (alpha, beta, gamma subunits) constitutively binds to CXCR1/CXCR2 receptor and activation by IL8 leads to beta and gamma subunits release from Galpha (GNAI2 in neutrophils) and activation of several downstream signaling pathways including PI3K and MAPK pathways. |
| Protein Name | Interleukin-8Il-8C-X-C Motif Chemokine 8ChemokineC-X-C Motif Ligand 8EmoctakinGranulocyte Chemotactic Protein 1Gcp-1Monocyte-Derived Neutrophil Chemotactic FactorMdncfMonocyte-Derived Neutrophil-Activating PeptideMonapNeutrophil-Activating Protein 1Nap-1Protein 3-10cT-Cell Chemotactic Factor Cleaved Into - Mdncf-AGcp/Il-8 Protein IvIl8/Nap1 Form I - Interleukin-8(Ala-Il-877Gcp/Il-8 Protein IiIl-8(1-77Il8/Nap1 Form IiMdncf-B - Il-8(5-77 - Il-8(6-77(Ser-Il-872Gcp/Il-8 Protein IIl8/Nap1 Form IiiLymphocyte-Derived Neutrophil-Activating FactorLynapMdncf-CNeutrophil-Activating FactorNaf - Il-8(7-77Gcp/Il-8 Protein VIl8/Nap1 Form Iv - Il-8(8-77Gcp/Il-8 Protein ViIl8/Nap1 Form V - Il-8(9-77Gcp/Il-8 Protein IiiIl8/Nap1 Form Vi |
| Database Links | Reactome: R-HSA-2559582Reactome: R-HSA-375276Reactome: R-HSA-380108Reactome: R-HSA-380994Reactome: R-HSA-418594Reactome: R-HSA-6783783Reactome: R-HSA-6785807 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-8 proteinIl-8 proteinC-X-C Motif Chemokine 8 proteinChemokine proteinC-X-C Motif Ligand 8 proteinEmoctakin proteinGranulocyte Chemotactic Protein 1 proteinGcp-1 proteinMonocyte-Derived Neutrophil Chemotactic Factor proteinMdncf proteinMonocyte-Derived Neutrophil-Activating Peptide proteinMonap proteinNeutrophil-Activating Protein 1 proteinNap-1 proteinProtein 3-10c proteinT-Cell Chemotactic Factor Cleaved Into - Mdncf-A proteinGcp/Il-8 Protein Iv proteinIl8/Nap1 Form I - Interleukin-8 protein(Ala-Il-877 proteinGcp/Il-8 Protein Ii proteinIl-8(1-77 proteinIl8/Nap1 Form Ii proteinMdncf-B - Il-8(5-77 - Il-8(6-77 protein(Ser-Il-872 proteinGcp/Il-8 Protein I proteinIl8/Nap1 Form Iii proteinLymphocyte-Derived Neutrophil-Activating Factor proteinLynap proteinMdncf-C proteinNeutrophil-Activating Factor proteinNaf - Il-8(7-77 proteinGcp/Il-8 Protein V proteinIl8/Nap1 Form Iv - Il-8(8-77 proteinGcp/Il-8 Protein Vi proteinIl8/Nap1 Form V - Il-8(9-77 proteinGcp/Il-8 Protein Iii proteinIl8/Nap1 Form Vi proteinCXCL8 proteinIL8 protein |
Information sourced from Uniprot.org