Human IL4I1 protein (Recombinant) (N-His) (STJP010956)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human IL4I1-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | IL4I1 |
| Gene ID | 259307 |
| Uniprot ID | OXLA_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Gln22-Asn505 |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity. Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells. Also regulates M2 macrophage polarization by inhibiting T-cell activation. Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2. |
| Protein Name | L-Amino-Acid OxidaseLaaoLaoInterleukin-4-Induced Protein 1Il4-Induced Protein 1Hil4i1Protein Fig-1Hfig1 |
| Database Links | Reactome: R-HSA-8964208 |
| Cellular Localisation | SecretedLysosomeCytoplasmic VesicleSecretory VesicleAcrosomeSecreted At The Immunological Synapse |
| Alternative Protein Names | L-Amino-Acid Oxidase proteinLaao proteinLao proteinInterleukin-4-Induced Protein 1 proteinIl4-Induced Protein 1 proteinHil4i1 proteinProtein Fig-1 proteinHfig1 proteinIL4I1 proteinFIG1 proteinUNQ636 proteinPRO1265 protein |
Information sourced from Uniprot.org